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Linkage of Amino Acid Variation and Evolution of Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein (Subtype B) with Usage of the Second Receptor

โœ Scribed by Yumi Yamaguchi-Kabata; Masahiro Yamashita; Sadayuki Ohkura; Masanori Hayami; Tomoyuki Miura

Publisher
Springer
Year
2004
Tongue
English
Weight
390 KB
Volume
58
Category
Article
ISSN
0022-2844

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The envelope glycoprotein (gpl20) of HIV-1 was labeled with fluorescein by using 6- [4,6-dichlorotriazinyl]aminofluorescein. The labeled glycoprotein was found to bind to CD4-positive CEM cells. Monoclonal antibody OKT4a but not OKT4 blocked this binding. Similar specific binding of fluorescein-labe