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Linkage mapping of highly informative DNA polymorphisms within the human interferon-α receptor gene on chromosome 21

✍ Scribed by McInnis, Melvin G.; Lutfalla, Georges; Slaugenhaupt, Susan; Petersen, Michael B.; Uze, Gilles; Chakravarti, Aravinda; Antonarakis, Stylianos E.


Book ID
122167715
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
702 KB
Volume
11
Category
Article
ISSN
0888-7543

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✍ Clair A. Francomano; Garry R. Cutting; Mary Kay McCormick; Mon Li Chu; Rupert Ti 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 765 KB

The genes that encode the alpha 1 (VI) and alpha 2 (VI) collagen chains, designated COL6A1 and COL6A2, map to human chromosomal band 21q22.3. Using pulsed-field gel electrophoresis and somatic cell hybrids, we found that COL6A1 and COL6A2 form a gene cluster on the most distal part of chromosome 21.