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Linkage information and bias in the presence of interference

โœ Scribed by DT Bishop; EA Thompson; D. C. Rao

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
652 KB
Volume
5
Category
Article
ISSN
0741-0395

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โœฆ Synopsis

Although interference is an important biological phenomenon, linkage analyses often ignore it for computational efficiency. In this paper we examine the effects of ignoring interference on estimates of recombination fraction, and the power of statistical tests to detect interference. We show that for gametes from phase-known triple heterozygotes, no bias in the recombination fraction for adjacent loci results from the assumption of lack of interference even if interference is present. However, for samples from painvise informative samples, there is bias introduced. An analytical form for this bias is obtained.

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