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Linkage-Disequilibrium-Based Binning Affects the Interpretation of GWASs

✍ Scribed by Andrea Christoforou; Michael Dondrup; Morten Mattingsdal; Manuel Mattheisen; Sudheer Giddaluru; Markus M. Nöthen; Marcella Rietschel; Sven Cichon; Srdjan Djurovic; Ole A. Andreassen; Inge Jonassen; Vidar M. Steen; Pål Puntervoll; Stéphanie Le Hellard

Book ID
113423205
Publisher
American Society of Human Genetics
Year
2012
Tongue
English
Weight
111 KB
Volume
90
Category
Article
ISSN
0002-9297

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Haplotype analysis of the linkage group
Haplotype analysis of the linkage group HLA-A:HLA-B:Bf and its bearing on the interpretation of the linkage disequilibrium
✍ K. Bender; A. Mayerová; R. Frank; C. Hiller; T. Wienker 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 275 KB

The analysis of 650 HLA-A:HAL-B:Bf three-factor haplotypes revealed significant associations only between alleles of the very closely linked genes HLA-A and HLA-B, and Bf, respectively. Most striking is the highly significnat association of the rare Bf variant F1 with HLA-B18 and of S1 with HLA-B13,