Linkage determination of alditol disaccharides using high-energy collision-induced dissociation spectra of sodium cationized molecules
✍ Scribed by Vladimír Kováčik; Ján Hirsch; Wigger Heerma
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 118 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-4198
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✦ Synopsis
Oligosaccharide alditols containing a deuterium atom at the alditol C-1 position can be used to obtain information about the masses and linkages of the various residues. The high-energy collision-induced dissociation (CID) spectra of the protonated compounds show mainly glycosidic bond cleavage with charge retention on the alditol containing Y-type ions. The CID spectra of the sodium-cationized compounds show additional fragment ions resulting from cross-ring cleavages. Moreover the elimination of methanol, formaldehyde and ethylene glycol molecules, as deuterium labelled or unlabelled species, appeared to provide a reliable criterion to determine the linkage positions at the alditol unit.