✦ LIBER ✦
Linkage detection by the Affected-Pedigree-Member method: What is really tested?
✍ Scribed by Dr. Marie-Claude Babron; Maria Martinez; Catherine Bonaïti-Pellié; Françoise Clerget-Darpoux
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 308 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies. 1993 Wiley-Liss, Inc.