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Linkage between tyrosine hydroxylase gene and affective disorder cannot be excluded in two of six pedigrees

✍ Scribed by Lim, Lionel C. C. ;Gurling, Hugh ;Curtis, David ;Brynjolfsson, Jon ;Petursson, Hannes ;Gill, Michael

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 517 KB
Volume: 48
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320480410

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Tyrosine hydroxylase (TH) is the ratelimiting enzyme in the synthesis of dopamine and noradrenaline. While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results. In order to clarify this situation, asso