Linkage between a hemoglobin locus and albinism in the Norway rat
โ Scribed by E. A. French; K. B. Roberts; A. G. Searle
- Book ID
- 104784972
- Publisher
- Springer
- Year
- 1971
- Tongue
- English
- Weight
- 462 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0006-2928
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โฆ Synopsis
Data are reported and analyzed from intercrosses between laboratory rats heterozygous for albinism (c) and for a structural gene (designated Hbb) determining the hemoglobin polymorphism previously reported in this species. The two loci are shown to be closely linked, with a map distance of about 5 crossover units (eM). This is discussed with referenee to the probable subunit structure of rat hemoglobin and to the similar linkage relationship which exists in the mouse.
๐ SIMILAR VOLUMES
A novel statistical model was developed to test for linkage disequilibrium between a polymorphic genetic marker locus and a locus underlying a quantitative trait (QTL) in natural populations using principles of analysis of variance of unbalanced data and analysis of regression involving data of non-