Linkage analysis with cohort effects: An application to X-linkage

✍ Scribed by Dr. Paul Van Eerdewegh

• Book ID: 102225540
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 349 KB
• Volume: 6
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370060147

✦ Synopsis

The LIPED program has been modified to incorporate cohort effects in a linkage analysis. Very significant positive lod scores are obtained between bipolar affective disorder and both the deutan and protan markers on the X-chromosome. Lod score methods are shown to be sensitive to the specification of the age of onset distributions and the parameters of the model of transmission.