Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study
β Scribed by Wen-Harn Pan; Jaw-Wen Chen; Cathy Fann; Yuh-Shan Jou; Sheng-Yeu Wu
- Book ID
- 106135264
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 49 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0340-6717
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Maturity-onset diabetes of the young (MODY) is a form of non-insulin-dependent diabetes mellitus characterised by an early age of onset and an autosomal dominant mode of inheritance. Only a proportion of cases are due to mutations in the glucokinase gene. We have studied five Caucasian MODY families
The possibility of linkage between the human insulin receptor gene locus and diabetes was examined in three Type 2 (non-insulin-dependent) diabetic families and one family with maturity onset diabetes of the young. Insulin receptor gene haplotypes were established using BglII, Rsal and Sstl restrict
## Abstract A previously published modelβfree linkage analysis of chromosome 2q33β35, highlighted by previous caseβcontrol studies and supported by withinβfamily analyses employing the transmission disequilibrium test, revealed evidence of sexβspecific linkage of the __CREB1__βcontaining region of