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Linkage analysis of the murineHyal-1 locus on chromosome 9

✍ Scribed by De Maeyer-Guignard, Jaqueline ;Cachard-Thomas, Annie ;De Maeyer, Edward

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
337 KB
Volume
258
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

We have recently described a new locus, Hyal‐1, which determines hyaluronidase variants in mouse serum. On the basis of segregation in recombinant inbred and congeric strains, Hyal‐1 was tentatively assigned to chromosome 9 (Fiszer‐Szafarz and De Maeyer, '89). In the present study we have performed a linkage analysis of Hyal‐1 using 156 backcross progeny of an interspecies cross of laboratory mice and Mus Spretus. Linkage was tested to two anchor loci on chromosome 9: d (dilute, a coat color locus) and Bgl‐s (a locus controlling β‐galactosidase activity). The gene order (from centromere) with intervening percentage recombination is d‐16.6 ( Β± 2.9)‐Hyal‐1‐10.9 ( Β± 2.4)‐Bgl‐s, indicating close linkage to H‐7 and Fv‐2.

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