Linkage analysis of bipolar illness with X-chromosome DNA markers: A susceptibility gene in Xq27-q28 cannot be excluded
✍ Scribed by De Bruyn, A. ;Raeymaekers, P. ;Mendelbaum, K. ;Sandkuijl, L. A. ;Raes, G. ;Delvenne, V. ;Hirsch, D. ;Staner, L. ;Mendlewicz, J. ;Van Broeckhoven, C.
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 821 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0148-7299
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✦ Synopsis
Transmission studies have supported the presence of a susceptibility gene for bipolar (BP) illness on the X-chromosome. Initial linkage studies with color blindness (CB), glucose-6-phosphate dehydrogenase (G6PD) deficiency, and the blood coagulation factor IX (F9) have suggested that a gene for BP illness is located in the Xq27-q28 region. W e tested linkage with several DNA markers located in Xq27-q28 in 2 families, MAD3 and MAD4, that previously were linked to F9 and 7 newly ascertained families of BP probands. Linkage was also examined with the gene encoding the a3 subunit of the gamma-amino butyric acid receptor (GABRA3), a candidate gene for BP illness located in this region. The genetic data were analyzed with the LOD score method using age-dependent penetrance of an autosomal dominant disease gene and narrow and broad clinical models. In MAD3 and MAD4 the multipoint LOD score data suggested a localization of a BPI gene again near F9. In the 7 new families the overall linkage data excluded the Xq27-q28 region. However, if the families were grouped according to their proband's phenotype BPI or BPII, a susceptibility gene for BPI disorder at the DXS52-FS cluster could not be excluded.