## Communicated by Nobuyoshi Shimizu The lattice corneal dystrophies (LCD) and granular corneal dystrophies (GCD) are autosomal dominant disorders of the corneal stroma. They are bilateral, progressive conditions characterized by the formation of opacities arising due to the deposition of insolubl
Linkage analysis in lattice corneal dystrophy
β Scribed by Kivlin, J. D. ;Lovrien, E. W. ;Maumenee, I. H. ;Bishop, D. T. ;Bias, W.
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 180 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0148-7299
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## Abstract Lattice corneal dystrophies (LCDs) are caused by mutations of the transforming growth factor betaβinduced gene (__TGFBI__, formerly __Ξ²igβh3__). LCD type IIIA (LCDIIIA) has been reported mostly from Japan. In this study, we demonstrate allelic homogeneity for Japanese patients with LCDI
We studied by high-resolution immunofluorescence (HRI) and by confocal laser scanning optical microscopy (CLSOM) the costameric organization of dystrophin and vinculin at the surface membrane of muscle fibers from 4 young boys with Becker muscular dystrophy (BMD). By HRI, the surface membrane of nor
Six autosomal dominant corneal dystrophies are caused by mutations in the TGFBI (BIGH3) gene on chromosome 5q31: three types of lattice corneal dystrophy (LCD), including type I and type IIIA, granular, Avellino (ACD), and Reis-Bucklers. Initially an exact genotype-phenotype correlation was reported