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Linkage analysis in familial melanoma kindreds to markers on chromosome 6p

✍ Scribed by Graeme J. Walker; Derek J. Nancarrow; Marilyn K. Walters; Jane M. Palmer; James L. Weber; Nicholas K. Hayward

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 554 KB
Volume: 59
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910590611

No coin nor oath required. For personal study only.

✦ Synopsis

Malignant melanoma occurs as a familial cancer in 5%-109/ 0 of cases, where it segregates in a manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine mapping studies of deletions in melanomas and recent linkage studies supports the location of a human melanoma predisposition gene on the short arm of chromosome 9. Evidence also exists for a melanoma gene on l p, indicating genetic

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