Linkage analyses using biochemical variants in mice. III. Linkage relationships of eleven biochemical markers

✍ Scribed by John J. Hutton; Thomas H. Roderick

• Book ID: 104784903
• Publisher: Springer
• Year: 1970
• Tongue: English
• Weight: 628 KB
• Volume: 4
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485782

✦ Synopsis

The linkage relationships of 11 loci concerned with protein or enzyme variation in the inbred mouse (Mus musculus) have been investigated. By means of a three-point cross, the order of the loci glucosephosphate isomerase (Gpi-1), albino (c), and hemoglobin fl-chain in linkage group I has been established as Gpi-c-Hbb. Similarly, the order of the loci autosomal glucose 6-phosphate dehydrogenase (Gpd-1), misty (m), and brown (b) in linkage group VIII has been established as Gpd-m-b. The levulinate dehydratase locus (Lv) in linkage group VIII which shows 5 +_ 2% recombination with the brown locus is near the anemia locus (an). The locus for malic dehydrogenase (Mdh-1) shows 10.1++_2.9% recombination with the dilute locus and 12.0++_ 6.5%o recombination with the luxoid locus. The tentative order of the three loci is d-Mdh-l-lu. Recombination between the isocitric dehydrogenase locus (Id-1) and the leaden locus (ln) is 16.7++_ 5.8%o and between Id-1 and the splotch locus (Sp) is 11.0+_5.4% in linkage group XIII. The tentative order of the three loci is ln-Sp-Id-1. Recombination between the lactic dehydrogenase regulatory locus (Ldr-1) and the microphthalmia locus (Mi wh) in linkage group XI is 28.7+_4.4%. Recombination between the phosphoglucomutase locus (Pgm-1) and the W-locus in linkage group XVII is 3.0++_ 1.7%o. The esterase-3 locus has not been placed in a linkage group and has been tested against markers on linkage groups