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LINGO1 polymorphisms are associated with essential tremor in Europeans

✍ Scribed by Sandra Thier; Delia Lorenz; Michael Nothnagel; Giovanni Stevanin; Alexandra Dürr; Almut Nebel; Stefan Schreiber; Gregor Kuhlenbäumer; Günther Deuschl; Stephan Klebe

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
150 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Essential tremor (ET) is one of the most common movement disorders. Former association studies focussing on candidate genes in ET found a number of risk variants but most of them were not replicated. Recently, a genome‐wide association study revealed two intronic sequence variants in the LINGO1 gene associated with ET. Here, we have confirmed association between sequence variants in the LINGO1 gene and the ET phenotype in independent German and French ET samples. The odds ratios for the identified intronic markers rs8030859 (P = 1.0×10^−4^), rs9652490 (P = 9.1×10^−4^), and rs11856808 (P = 3.6×10^−2^) were 1.72 (CI 1.31‐2.26), 1.61 (CI 1.21‐2.14), and 1.30 (CI 1.02‐1.66), respectively, in our German sample. LINGO1 is an interesting candidate gene because it plays a key role in central nervous system biology, is selectively expressed in the nervous system, and is an inhibitor of oligodendrocyte differentiation and neuronal myelination. Our study gives further evidence that LINGO1 acts as a susceptibility gene for ET. © 2010 Movement Disorder Society

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