## Abstract The myelin sheath, which is wrapped around the axons in the brain, can be affected by many diseases, resulting in cognitive and physical disability. Other work showed water in the myelin sheath has a __T__~2~ ≈ 15 ms. The current standard technique to estimate the fraction of myelin wat
Linear combination filtering for T2-selective imaging of the knee
✍ Scribed by Logi Vidarsson; Garry E. Gold; Brian Hargreaves; John M. Pauly
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 637 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Recently a novel T~2~ selective imaging method based on linear combination (LC) filtering was developed. By linearly combining images acquired with different echo times LC filtering is able to generate images showing only tissues with a preselected range of T~2~ relaxation times. In this study the use of LC filtering in knee imaging was investigated. Three LC filters were designed: a short LC filter for imaging the knee meniscus, a medium LC filter for articular cartilage, and a long LC filter for synovial fluid. To verify the filter designs, eight phantoms with different T~2~ relaxation times were imaged. In addition, in vivo images were acquired from four asymptomatic volunteers and a subject with cartilage damage. T~2~ maps were also generated using the same source images. Signal‐to‐noise ratio (SNR) measurements were made of the meniscus, cartilage, and fluid regions on the three LC filtered images. The highest SNR was seen in the target tissue on each of the LC filtered images. LC filtering is a new method that can selectively image knee tissues based on their T~2~. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
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