Cholesterol reutilization during myelina
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Jeffry F. Goodrum; Peter G. Pentchev
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Article
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1997
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John Wiley and Sons
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English
⚖ 333 KB
Niemann-Pick C (NPC) disease is an autosomal recessive lipidosis characterized by lysosomal accumulations of unesterified cholesterol. Cultured NPC cells exhibit a defect in the intracellular trafficking of LDL-derived cholesterol that leads to lysosomal accumulations of unesterified cholesterol. We