𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Linear Azo Polymer Containing Conjugated 5,5′-Azodisalicylic Acid Segments in the Main Chain: Synthesis, Characterization, and Degradation

✍ Scribed by Junying Lai; Li-Qun Wang; Kehua Tu; Changsheng Zhao; Weilin Sun

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
144 KB
Volume
26
Category
Article
ISSN
1022-1336

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Summary: Copolymers of poly(ethylene oxide) (PEO) and 5,5′‐azodisalicylic acid (Olsalazine, OLZ) were synthesized and evaluated by hydrolysis and in‐vitro biodegradation with azoreductase. It was found that changing the molecular weight of the PEO blocks affected the loading ratio of OLZ, and resulted in significant differences in the hydration and degradability of the copolymers. These novel azo‐containing copolymers can be used in colon‐specific drug delivery.

Release of 5‐ASA from OLZ and PEO‐OLZ copolymers incubated with rat cecum content in the presence of benzyl viologen and α‐D‐glucose.

magnified imageRelease of 5‐ASA from OLZ and PEO‐OLZ copolymers incubated with rat cecum content in the presence of benzyl viologen and α‐D‐glucose.

📜 SIMILAR VOLUMES

New π-Conjugated Polymers Containing 1,3
New π-Conjugated Polymers Containing 1,3,5-Triazine Units in the Main Chain: Synthesis and Optical and Electrochemical Properties of the Polymers
✍ Shijie Ren; Qiang Fang; Yi Lei; Haitao Fu; Xiaoyao Chen; Junping Du; Amin Cao 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

## Abstract **Summary:** Three new soluble __π__‐conjugated polymers containing 1,3,5‐triazine units in the main chain, Pa–Pc, were synthesized. The polymers showed optical properties in solution that were mainly dependant on the properties of the substituting R groups, on the triazine ring. Hence,