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Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2

✍ Scribed by Joomyeong Kim; Anne Bergmann; Susan Lucas; Roger Stone; Lisa Stubbs

Book ID
116981250
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
785 KB
Volume
84
Category
Article
ISSN
0888-7543

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We have identified a novel Kruppel-type zinc finger (ZF) gene, SKAT-2, which is selectively expressed by murine Th2 cells. The protein encoded by this gene has 14 C2H2-type ZF tandemly arrayed at its C terminus and N-terminal SCAN box and KRAB domains. SKAT-2 is tissue restricted in expression at th