✦ LIBER ✦
Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines
✍ Scribed by Hector Mayani; Wieslawa Dragowska; Peter M. Lansdorp
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 827 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
✦ Synopsis
Different models have been proposed to explain lineage commitment in hemopoiesis. Some suggest that lineage commitment occurs in a stochastic manner without the direct influence of extracellular factors; others postulate that cytokines determine whether multipotent cells will become erythroid or granulocyte/ macrophage progenitors. In the present study, the patterns of proliferation and differentiation of i nd ividual I y sorted human cord blood-derived prim i tive he-