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LINE-1 Hypomethylation in Noncancerous Esophageal Mucosae is Associated with Smoking History

✍ Scribed by Shigaki, Hironobu; Baba, Yoshifumi; Watanabe, Masayuki; Iwagami, Shiro; Miyake, Keisuke; Ishimoto, Takatsugu; Iwatsuki, Masaaki; Baba, Hideo

Book ID
121011543
Publisher
Springer
Year
2012
Tongue
English
Weight
467 KB
Volume
19
Category
Article
ISSN
1068-9265

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## Abstract The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and __BRAF__ mutation. Genome‐wide hypomethylation may also play an important role in genomic instability. How