Linarienone, a new cis-clerodane-type diterpene from the subterranean part of Linaria japonica Miq.

✍ Scribed by Isao Kitagawa; Minoru Yoshihara; Toshiyuki Kamigauchi

• Book ID: 104244095
• Publisher: Elsevier Science
• Year: 1977
• Tongue: French
• Weight: 235 KB
• Volume: 18
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)92980-6

✦ Synopsis

During the course of studies on the chemical constituents of Linaria japonica Miq. (unran in Japanese, Scrophulariaceae), we have first elucidated the structure of linarioside (A), 1) which was isolated from the water-soluble portion of epigeous and subterranean parts of the plant and was the first example of chlorine-containing iridold-glucoside, and afterwards, we have established the structure of a cis-clerodane-type diterpene dialdehyde named linaridial -(&2) which was obtained as the major component of the ether extractive of fresh subterranean part. In a continuing study on the ether-soluble portion, we have recently isolated another new cis-clerodane-type diterpene designated as linarienone (L)(ca. 1% from the ether ext.) whose structure elucidation is the subject of this communication. Linarienone (L), C2,H4005, 3) oil, [Oc], +30° (CHC13), possesses an angelate group IUV A