Limiting-dilution analysis of T cell reactivity to mycobacterial antigens in peripheral blood and synovium from rheumatoid arthritis patients
β Scribed by F. D. CRICK; P. A. GATENBY
- Book ID
- 108698401
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 505 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0009-9104
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π SIMILAR VOLUMES
Rheumatoid arthritis is a T cell-mediated autoimmune disease. The lack of knowledge of the involved target antigens severely hampers research on relevant T cells in patients. Here we describe the functional analysis of freshly isolated T cells from the peripheral blood and the site of the lesion (sy
## Abstract Recent evidence has pointed to the mycobacterial 65βkDa heatβshock protein (hsp 65) as an antigen that may be important in the pathogenesis of rheumatoid arthritis (RA). Using limiting dilution analysis the frequency of purified protein derivative of tuberculin (PPD) and hsp 65βresponsi