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Limited sufficiency of antigen presentation by dendritic cells in models of central nervous system autoimmunity

โœ Scribed by Gregory F. Wu; Kenneth S. Shindler; Eric J. Allenspach; Tom L. Stephen; Hannah L. Thomas; Robert J. Mikesell; Anne H. Cross; Terri M. Laufer

Book ID
116614330
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
617 KB
Volume
36
Category
Article
ISSN
0896-8411

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In the normal central nervous system (CNS) expression of MHC class II is minimal, but has been found to be highly up-regulated on microglia cells in experimental autoimmune encephalitis (EAE). Here we used the EAE model to examine the regulation of expression of the class II transactivator (CIITA),