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Limited Reactivity of Formyl Chloride with Glutathione and Relevance to Metabolism and Toxicity of Dichloromethane

✍ Scribed by Watanabe, Kengo; Guengerich, F. Peter


Book ID
120923270
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
155 KB
Volume
19
Category
Article
ISSN
0893-228X

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An HPLC-based assay system has been developed to measure the reactivity of agrochemicals with glutathione (GSH) with and without catalysis by glutathione transferases (GSTs). Metabolism-related parameters based on second-order related rate constants from non-enzymatic GSH and enzymatic GSH ] GST ass