Limited memory impairment after temazepam

✍ Scribed by Sandra E. File; Eileen M. Joyce; Emma Fluck; Eveline De bruin; Farid Bazari; Hasmita Nandha; Lawrence Fitton; Shaumik Adhiya

• Book ID: 101280447
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 163 KB
• Volume: 13
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199803)13:2<127::aid-hup962>3.0.co;2-r

✦ Synopsis

In order to examine the eects of temazepam on memory, a battery of cognitive tests and analogue mood ratings were given to healthy volunteers after oral administration of 5, 10 and 30 mg. The lowest dose had no eect and 10 mg only signi®cantly increased self-ratings of well-being. Temazepam (30 mg) signi®cantly improved recall of items learned prior to drug administration, but impaired recall and recognition of word lists acquired after drug administration. However, when retrieval was assessed indirectly using a backwards reading task there was no impairment, indicating that automatic information processing was unaected. Temazepam (30 mg) signi®cantly reduced self-ratings of anxiety and increased those of sedation. It also signi®cantly impaired performance in symbol copying, digit-symbol substitution and number cancellation tasks. It is striking that, at a dose that was sedative and impaired many aspects of performance, temazepam nonetheless improved retrieval of items learned prior to drug administration.