Müller cell swelling, glutamate uptake,
Müller cell swelling, glutamate uptake, and excitotoxic neurodegeneration in the isolated rat retina
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Yukitoshi Izumi; Charity O. Kirby; Ann M. Benz; John W. Olney; Charles F. Zorums
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Article
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1999
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John Wiley and Sons
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English
⚖ 410 KB
We characterized morphological effects of the endogenous excitotoxin, glutamate in ex vivo retinal segments prepared from 30-day-old rats. Initial changes induced by glutamate consisted of reversible, sodium-dependent Mu ¨ller cell swelling. This glial swelling was mimicked by glutamate transport su