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Limitations to the Development of Humanized Antibody Producing Chinese Hamster Ovary Cells Using Glutamine Synthetase-Mediated Gene Amplification

โœ Scribed by Seung Chul Jun; Min Soo Kim; Hyo Jeong Hong; Gyun Min Lee

Book ID
109387387
Publisher
American Institute of Chemical Engineers
Year
2006
Tongue
English
Weight
352 KB
Volume
22
Category
Article
ISSN
8756-7938

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Chinese hamster ovary cell production of recombinant tissue-type plasminogen activator (t-PA) was increased by amplification of cotransfected dihydrofolate reductase cDNA using stepwise adaptation to increasing methotrexate (MTX) concentrations. The highest producing clones were isolated at 5 ยตM MTX