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Limitations of targeted therapy with sorafenib in elderly high-risk myelodysplastic syndrome and acute myeloid leukemia

✍ Scribed by Wei, Andrew; Tan, Peter


Book ID
126958204
Publisher
Informa plc
Year
2012
Tongue
English
Weight
143 KB
Volume
54
Category
Article
ISSN
1042-8194

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## Abstract ## BACKGROUND Imatinib mesylate is a selective tyrosine kinase inhibitor of c‐abl, bcr/abl, c‐kit, and platelet‐derived growth factor‐receptor (PDGF‐R). c‐kit is expressed in most patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) and PDGF has been implicated