Limitations of Point-of-Care Testing in the ED or ICU: A Role for Regional Centralized Toxicology Laboratories

Loss of heterozygosity mapping in Wilms

Loss of heterozygosity mapping in Wilms tumor indicates the involvement of three distinct regions and a limited role for nondisjunction or mitotic recombination

✍ Max J. Coppes; Laura Bonetta; Annie Huang; Paul Hoban; Susan Chilton-MacNeill; C 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 748 KB

## Abstract Loss of heterozygosity (LOH) for polymorphic markers is a frequently occurring event in some tumors, reflecting the role of allele loss in the development of these tumors. We have determined LOH in 38 cases of Wilms tumor for the 2 known loci on chromosome arm 11p and for a newly detect