Limb reduction defects in humans associated with prenatal isotretinoin exposure

Limb reduction defects in the A/J mouse

Limb reduction defects in the A/J mouse strain associated with maternal blood loss

✍ Fawcett, Lynda B.; Buck, Susan J.; Brent, Robert L. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB

We previously described a high incidence of digit/limb anomalies in the offspring of A/J mice subjected to surgery on day 12.5 postconception (p.c.), but not in the offspring of untreated control mice. To investigate the cause of these defects, we compared the offspring of mice in experimental group