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Limb deficiencies, chorion villus sampling, and advanced maternal age

✍ Scribed by Halliday, Jane ;Lumley, Judith ;Sheffield, Leslie J. ;Lancaster, Paul A. L.


Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
339 KB
Volume
47
Category
Article
ISSN
0148-7299

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Chorion villus sampling (CVS) is a widely used technique in first trimester prenatal diagnosis. In the early 1990s, two clusters of babies with limb defects following CVS were reported, raising the possibility of a causal association between early CVS and transverse limb deficiency. The evidence for

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restrictive definition of TDDs (all five digits affected) may limit the ability to evaluate the association between CVS and TDDs in populations in whom CVS is usually performed at or after 10 weeks' gestation; and highlight the necessity to consider gestational age in any evaluation of the relative

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Report of NICHD Workshop, 19931 of transverse limb deficiencies sometimes associated with the Hanhart or Mobius syndromes, have suggested a possible role of chorionic villus biopsy (CVS), particularly if performed between 56 and 66 days of gestation. Variability in the incidence of these abnormaliti