The effect of intracellular protons (Hi +) on the inward rectifier K + channel of the guinea-pig ventricular ceil membrane was examined, using the patch-clamp technique. The inward single-channel current was recorded in "inside-out" and "outside-out" patch configurations, while the pH of the solutio
Li+inhibition of membrane current responses to epinephrine in guinea-pig ventricular cells
โ Scribed by S. Matsuoka; A. Noma; T. Powell
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 296 KB
- Volume
- 415
- Category
- Article
- ISSN
- 0031-6768
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๐ SIMILAR VOLUMES
Transient inward currents (Iti) during oscillations of intracellular [Ca2+] ([Ca2+]i) in ventricular myocytes have been ascribed to Na/Ca exchange. We have investigated whether other Ca2+-dependent membrane currents contribute to Iti in single guinea-pig ventricular myocytes, by examining membrane c
Patch-clamp techniques were used to study the effects of pinacidil on the adenosine-5'-triphosphate (ATP)sensitive K + channel current in guinea-pig ventricular myocytes. In inside-out patches, the ATP-sensitive K + channel current could be recorded at an internal ATP concentration of 0.5 mM or tess