## Abstract __Purposes__. (1) To investigate the efficiency of direct in vivo adeno‐associated virus (AAV) vector‐mediated gene transduction to chondrocytes in relation to normal and injured articular cartilage. (2) To evaluate the effects of ultra‐violet light‐activated gene transduction (LAGT) in
✦ LIBER ✦
Light-activated gene transduction enhances adeno-associated virus vector–mediated gene expression in human articular chondrocytes
✍ Scribed by Michael Ulrich-Vinther; Michael D. Maloney; J. Jeffrey Goater; Kjeld Søballe; Mary B. Goldring; Regis J. O'Keefe; Edward M. Schwarz
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 398 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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## Abstract This study quantified and compared the transduction efficiencies of adenoviral (Ad), Arg‐Gly‐Asp (RGD)‐modified Ad, adeno‐associated viral serotype 2 (AAV2), and self‐complementary AAV2 (scAAV2) vectors within full‐thickness osteoarthritic (OA) and unaffected canine cartilage explants i