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Ligation of RNA-Containing Duplexes by Vaccinia DNA Ligase

✍ Scribed by Sekiguchi, JoAnn; Shuman, Stewart


Book ID
126032936
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
348 KB
Volume
36
Category
Article
ISSN
0006-2960

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NAD(+)-dependent DNA ligases are essential enzymes in bacteria, with the most widely studied of this class of enzymes being LigA from Escherichia coli. NAD(+)-dependent DNA ligases comprise several discrete structural domains, including a BRCT domain at the C-terminus that is highly-conserved in thi