๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Ligands for EPH-related tyrosine kinase receptors are developmentally regulated in the CNS

โœ Scribed by M. K. Carpenter; H. Shilling; T. Vandenbos; M. P. Beckmann; D. P. Cerretti; J. N. Kott; L. E. Westrum; B. L. Davison; F. A. Fletcher

Book ID
102911585
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
822 KB
Volume
42
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

โœฆ Synopsis

Elk is a member of the eph family of receptor-like tyrosine kinases. Although its function is unknown, elk is postulated to play a role in nervous system development. Using Northern analysis, we examined the developmental regulation of RNAs encoding elk, and several ligands for the eph family of RTKs, the LERKs. Expression of elk, LERK-1, and LERK-2 RNAs is high in all regions examined in the embryonic and postnatal rat brain and decreases to low levels with age. One exception is the adult olfactory bulb which continues to express a moderate level of LERK-2. In contrast, moderate LERK-4 expression was limited to the developing hippocampus and cerebral cortex. These data indicate that elk and some of the LERKs may play a role in nervous system development, maintenance, and/or regeneration.

๐Ÿ“œ SIMILAR VOLUMES

Expression and subcellular localization
Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons
โœ Sabrina Paganoni; Adriana Ferreira ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 580 KB

## Abstract Ror1 and Ror2 are two novel receptor tyrosine kinases that have been implicated in neuronal differentiation in __Caenorhabditis elegans__. As a first step toward elucidating their role in the mammalian brain, we analyzed their expression and localization patterns in hippocampal neurons.

Diverse roles for the Eph family of rece
Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis
โœ Masaru Nakamoto; Andrew D. Bergemann ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 94 KB

The Eph family of receptor tyrosine kinases and their cell-presented ligands, the ephrins, are frequently overexpressed in a wide variety of cancers, including breast, small-cell lung and gastrointestinal cancers, melanomas, and neuroblastomas. In particular, one Eph family member, EphA2, is overexp