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Ligand-Free-Palladium-Catalyzed Direct 4-Arylation of Isoxazoles Using Aryl Bromides

✍ Scribed by Yacoub Fall; Céline Reynaud; Henri Doucet; Maurice Santelli


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
764 KB
Volume
2009
Category
Article
ISSN
1434-193X

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Regioselective C-2 or C-5 Direct Arylati
✍ Julien Roger; Henri Doucet 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB 👁 2 views

## Abstract A simple and atom‐economical procedure for the regioselective C‐2 or C‐5 arylation of pyrroles __via__ a CH bond activation is reported. Only 0.5–0.01 mol% of commercially available and air‐stable ligand‐free palladium(II) acetate [Pd(OAc)~2~] was employed as the catalyst. The presence