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Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation

✍ Scribed by Cele Abad-Zapatero; Ognjen Perišić; John Wass; A. Patrícia Bento; John Overington; Bissan Al-Lazikani; Michael E. Johnson

Book ID
113569155
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
516 KB
Volume
15
Category
Article
ISSN
1359-6446

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✍ Daniel Blasi; Gemma Arsequell; Gregori Valencia; Joan Nieto; Antoni Planas; Mart 📂 Article 📅 2011 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 721 KB

## Abstract We have previously reported the design and synthesis of ligands that stabilize Transthyretin protein (TTR) in order to obtain therapeutically active compounds for Familial Amyloid Polyneuropathy (FAP). We are hereby reporting a drug design strategy to optimize these ligands and map them