Ligand depletion negatively controls the mitogenic activity of epidermal growth factor
β Scribed by Monique L.M. van de Poll; Walter van Rotterdam; Mireille M. Gadellaa; Saskia Jacobs-Oomen; Everardus J.J. van Zoelen
- Book ID
- 118506051
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 319 KB
- Volume
- 304
- Category
- Article
- ISSN
- 0014-4827
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Normal rat kidney (NRK) fibroblasts are immortalized cells that are strictly dependent on externally added growth factors for proliferation. When cultured in the presence of epidermal growth factor (EGF) as the only growth stimulating hormone, these cells have a normal phenotype and undergo density-