Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-β signaling

TGF-β-induced expression of tissue inhib

TGF-β-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor

✍ Hamid Yaqoob Qureshi; Judith Sylvester; Mohammed El Mabrouk; Muhammad Zafarullah 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 422 KB

## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,