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Ligand-Dependent Inhibition and Reversal of Tau Filament Formation†

✍ Scribed by Chirita, Carmen; Necula, Mihaela; Kuret, Jeff

Book ID
111906132
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
268 KB
Volume
43
Category
Article
ISSN
0006-2960

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## Abstract The neuropathology of Alzheimer's disease (AD) and other tauopathies is characterized by filamentous deposits of the microtubule‐associated protein tau, but the relationship between tau polymerization and neurotoxicity is unknown. Here, we examined effects of filamentous tau on fast axo