𝔖 Bobbio Scriptorium
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Lifetime menstrual activity — Indicator of breast cancer risk

✍ Scribed by M. Rautalahti; D. Albanes; J. Virtamo; J. Palmgren; J. Haukka; O. P. Heinonen

Publisher
Springer
Year
1993
Tongue
English
Weight
785 KB
Volume
9
Category
Article
ISSN
0393-2990

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✦ Synopsis

A case-control study of 67 cases of breast cancer and 157 controls was conducted to investigate the role of different behavioral, reproductive, and hormonal factors and to develop a unifying indicator of breast cancer risk. The results confirm previous reports of the influence of smoking on the risk of breast cancer. Age at menarche was found to be a risk factor among the premenopausal women. Late age at menopause was suggestive of an increase in risk. Long use of oral contraceptive or estrogen supplementation were risk-enhancing both pre- and postmenopausally. Lifetime duration of menstrual activity (LMA) combines age at menarche and menopause, parity, and lactation into a biologically plausible model. Our findings concerning LMA support its role as a determinant of breast cancer.

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