Life-style and environmental factors in the development of nasal NK/T-cell lymphoma: A case–control study in East Asia
✍ Scribed by Jing-Xian Xu; Yoshihiko Hoshida; Woo-Ick Yang; Hidenori Inohara; Takeshi Kubo; Gwi-Eon Kim; Joo-Heon Yoon; Shizuo Kojya; Nobuyuki Bandoh; Yasuaki Harabuchi; Kouichiro Tsutsumi; Izumi Koizuka; Xin-Shan Jia; Mitsunori Kirihata; Hideaki Tsukuma; Katsuyuki Aozasa
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- French
- Weight
- 77 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Cases of nasal NK/T‐cell lymphoma (NKTCL) occur occasionally in Asian and Latin American countries but rarely in Western countries. The etiological role of life‐style and environmental factors in nasal NKTCL was investigated. Five university hospitals in Japan and one each in Korea and China participated in this study; a total of 88 cases and 305 hospital controls were accrued during 2000–2005. The odds ratio (OR) of NKTCL obtained after adjustments of age, sex and country was 4.15 (95% confidence interval (CI), 1.74–9.87) for farmers, 2.81 (CI, 1.49–5.29) for producers of crops, 4.01 (CI, 1.99–8.09) for pesticide users, 11.65 (CI, 1.17–115.82) for residents near garbage burning plants, 2.95 (CI, 1.25–6.95) for former drinkers, and 0.49 (CI, 0.23–1.04) for current smokers. The ORs for crop producers, who minimized their exposure to pesticides by using gloves and glasses, and sprinkling downwind at the time of pesticide use, were 3.30 (95% CI, 1.28–8.54), 1.18 (95% CI, 0.11–12.13) and 2.20 (95% CI, 0.88–5.53), respectively, which were lower than those for producers who did not take these precautions. Exposure to pesticides and chemical solvents could be causative of NKTCL. Taken together, life‐style and environmental factors might be risk factors for NKTCL. © 2006 Wiley‐Liss, Inc.