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Life span shortening of normal fibroblasts by overexpression of BCL-2: a result of potent increase in cell death

โœ Scribed by Tsutomu Kumazaki; Masao Sasaki; Masahiko Nishiyama; Yasuhiro Teranishi; Hiroshi Sumida; Akira Eboshida; Youji Mitsui


Book ID
117099794
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
416 KB
Volume
285
Category
Article
ISSN
0014-4827

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Previous studies on cell cycle regulation in the ocular lens using transgenic mice have shown that inactivation of the retinoblastoma tumor suppressor protein (pRb) can cause postmitotic lens fiber cells to enter the cell cycle. However, when the p53 gene and protein are intact, inactivation of pRb