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Lidocaine and pentobarbital: A potentially lethal drug-drug interaction

✍ Scribed by J. LeLorier

Book ID
116072341
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
197 KB
Volume
44
Category
Article
ISSN
0041-008X

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Nonlethal doses of methylxanthines (caffeine or theophyline) produced dose-dependent lethality in rats pretreated with isoniazid. lsoniazid pretreatment did not alter theophylline concentration in blood or brain, suggesting that the drug interaction was not due to altered distribution or metabolism