Lichen planus-like eruption following autologous bone marrow transplantation for chronic myeloid leukaemia

✍ Scribed by John A Pagliaro; Stephen White; Geoffrey Strutton; Deirdre Guerin

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 221 KB
• Volume: 42
• Category: Article
• ISSN: 0004-8380
• DOI: 10.1046/j.1440-0960.2001.00512.x

✦ Synopsis

SUMMARY

A 47‐year‐old female treated with an autologous bone marrow transplant and cytotoxic chemotherapy developed a lichen planus‐like eruption 12 months later. It involved the skin and oral mucosa, with the histological features of a lichenoid graft‐versus‐host reaction, including satellite cell necrosis. This eruption developed de novo. The eruption resolved with topical betamethasone valerate 0.1% cream despite the ongoing use of the immunomodulatory agent interferon‐α2b. Such a reaction in an autologous setting has only been described once previously.