## Abstract Mutations in codon 133 of __p53__, which cause the loss of the Δ133 isoform(s) expression, are very frequent in the Li–Fraumeni (LF) and Li–Fraumeni‐like (LFL) syndromes. In sporadic cancers, silent __p53__ mutations are correlated with exonic splicing enhancers (ESEs) and exonic methyl
Li-Fraumeni and Li-Fraumeni-like syndrome among children diagnosed with pediatric cancer in Southern Brazil
✍ Scribed by Giacomazzi, Juliana; Selistre, Simone G.; Rossi, Cristina; Alemar, Barbara; Santos-Silva, Patricia; Pereira, Fernando S.; Netto, Cristina B.; Cossio, Silvia L.; Roth, Daniela E.; Brunetto, Algemir L.; Zagonel-Oliveira, Marcelo; Martel-Planche, Ghyslaine; Goldim, Jose R.; Hainaut, Pierre; Camey, Suzi A.; Ashton-Prolla, Patricia
- Book ID
- 121730496
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 439 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Germline __TP53__ mutations are found in Li‐Fraumeni syndrome (LFS) patients, predisposed to soft tissue sarcoma and other malignancies. The mutations and succeeding genetic events are thought to cause LFS‐associated cancer, whose genetic alterations have rarely been investigated. Here,