Lewis acid-promoted addition of methylenecyclopropanes to aldehydes and ketones

✍ Scribed by Katsukiyo Miura; Mizuki Takasumi; Takeshi Hondo; Hiroshi Saito; Akira Hosomi

• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 242 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00981-7

✦ Synopsis

In the presence of TiCi4, me~ylenecyclopropane (la) easily reacted with Jdln~u~tlc aldehydes to give the p-(chiorome~yl)allylate~ products 2 in good yields along with a small amount of the methylenetetrahydrofurans 3. The reacti~ with chiral a-and ~-alkoxy aldehydes lwoceeded with high levels of cl~latioG control.