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Lewis Acid Catalyzed Room-Temperature Michaelis–Arbuzov Rearrangement

✍ Scribed by Pierre-Yves Renard; Philippe Vayron; Eric Leclerc; Alain Valleix; Charles Mioskowski


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
103 KB
Volume
115
Category
Article
ISSN
0044-8249

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## Abstract An efficient and mild access to mixed dimethylalkynylaluminum reagents has been developed __via__ a direct Lewis base‐catalyzed alumination of terminal alkynes by trimethylaluminum. The use of bis(trimethylsilyl)methylamine enables the metalation at room temperature with only 1% of cata